Regiospecific Hydration of γ-Hydroxy-α,β-acetylenic Esters: A Novel Asymmetric Synthesis of Tetronic Acids
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چکیده
منابع مشابه
wuthering heights and the concept of marality/a sociological study of the novel
to discuss my point, i have collected quite a number of articles, anthologies, and books about "wuthering heights" applying various ideas and theories to this fantastic story. hence, i have come to believe that gadamer and jauss are rightful when they claim that "the individaul human mind is the center and origin of all meaning," 3 that reading literature is a reader-oriented activity, that it ...
15 صفحه اولHighly efficient asymmetric hydrogenation of cyano-substituted acrylate esters for synthesis of chiral γ-lactams and amino acids.
A highly efficient and enantioselective synthesis of γ-lactams and γ-amino acids by Rh-catalyzed asymmetric hydrogenation has been developed. Using the Rh-(S,S)-f-spiroPhos complex, under mild conditions a wide range of 3-cyano acrylate esters including both E and Z-isomers and β-cyano-α-aryl-α,β-unsaturated ketones were first hydrogenated with excellent enantioselectivities (up to 98% ee) and ...
متن کاملHighly efficient macrolactonization of ω-hydroxy acids using benzotriazole esters: synthesis of Sansalvamide A.
A facile and mild macrolactonization reaction of ω-hydroxy acids was developed based on the transesterification of benzotriazole esters. Treatment of ω-hydroxy acids with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and 1-hydroxy benzotriazole (HOBT) in chloroform provided macrolactones in excellent yields. The reactions were performed under basic, neutral and acidic conditions using N,...
متن کاملAMild Method for the Preparation of g-Hydroxy- a,b-Acetylenic Esters**
The alkynylation of a carbonyl compound is a powerful reaction for forming a carbon–carbon s bond. Highly functionalized g-hydroxy-a,b-acetylenic esters RCH(OH)C C CO2Me (A) are promising synthetic intermediates that can be used as precursors to a variety of complex molecules. Since the procedure was reported by Midland et al., alcohols A have mainly been prepared by the treatment of aldehydes ...
متن کامل1 Tetronic Acids
Tetronic acids belong to the class of 4-hydroxybutenolides that are characterized by a 4-hydroxy-2(5H)-furanone ring, as it can be seen in the generic structure of Scheme 1.1 [1]. This type of five-membered vinylogous acids can bemet in twomain tautomeric forms (1 and 2) with enol structure 1 being the one that predominates. Tetronic acid is a substructural element of many natural products of v...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2006
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol060377v